Yoichi Ishitsuka Selected Research

ozagrel

1/2013	Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.
10/2009	A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs.
4/2004	Involvement of thromboxane A2 (TXA2) in the early stages of oleic acid-induced lung injury and the preventive effect of ozagrel, a TXA2 synthase inhibitor, in guinea-pigs.

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Yoichi Ishitsuka Research Topics

Disease

14	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2022 - 01/2014
5	Necrosis 10/2020 - 01/2013
5	Lung Injury 10/2009 - 04/2003
5	Acute Lung Injury 10/2009 - 04/2003
4	Chronic Renal Insufficiency 06/2021 - 12/2012
4	Body Weight (Weight, Body) 04/2020 - 01/2010
3	Apnea 01/2016 - 06/2013
2	Acute Liver Failure (Fulminant Hepatic Failure) 01/2020 - 02/2018
2	Asthma (Bronchial Asthma) 01/2020 - 01/2013
2	Inflammation (Inflammations) 08/2019 - 09/2015
2	Kidney Diseases (Kidney Disease) 08/2019 - 01/2019
2	Hepatomegaly 05/2019 - 03/2019
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/2019 - 04/2015
2	Pain (Aches) 01/2019 - 12/2012
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 09/2015 - 01/2010
2	B-Cell Lymphoma (Lymphoma, B Cell) 09/2014 - 01/2013
2	Hypoxia (Hypoxemia) 06/2013 - 09/2004
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 07/2009 - 04/2004
1	Melanoma (Melanoma, Malignant) 01/2021
1	Ototoxicity 01/2021
1	Hepatoblastoma 10/2020
1	Constipation 04/2020
1	Bronchial Spasm 01/2020
1	Hepatitis 01/2020
1	Fibrosis (Cirrhosis) 08/2019
1	Sarcopenia 08/2019
1	Hypertension (High Blood Pressure) 01/2019
1	Acute Kidney Injury (Acute Renal Failure) 01/2019
1	Herpes Zoster 01/2019
1	Drug-Related Side Effects and Adverse Reactions 01/2017
1	Anemia 01/2017
1	Venous Thrombosis (Deep-Vein Thrombosis) 01/2017
1	Venous Thromboembolism 01/2017
1	Skin Diseases (Skin Disease) 07/2016
1	Edema (Dropsy) 07/2016
1	Atherosclerosis 04/2016
1	Sepsis (Septicemia) 11/2015
1	Hypoalbuminemia 11/2015
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 11/2015

Drug/Important Bio-Agent (IBA)

10	CholesterolIBA 01/2022 - 01/2015
7	CyclodextrinsIBA 01/2022 - 01/2014
7	Pharmaceutical PreparationsIBA 06/2021 - 09/2004
7	Acetaminophen (Paracetamol)FDA LinkGeneric 10/2020 - 12/2012
5	Oleic Acid (Oleate)IBA 10/2009 - 04/2003
4	Messenger RNA (mRNA)IBA 07/2016 - 10/2009
3	Lactose FDA LinkGeneric 01/2022 - 01/2015
3	Transaminases (Aminotransferases)IBA 10/2020 - 01/2014
3	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2020 - 12/2012
3	Transcription Factor CHOPIBA 09/2015 - 01/2013
3	ozagrelIBA 01/2013 - 04/2004
2	SphingomyelinsIBA 01/2022 - 04/2016
2	GlycolipidsIBA 01/2022 - 04/2015
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 04/2003
2	JNK Mitogen-Activated Protein KinasesIBA 01/2020 - 09/2014
2	CreatinineIBA 08/2019 - 01/2014
2	Analgesics (Analgesic Drugs)IBA 01/2019 - 02/2018
2	sacranIBA 07/2016 - 01/2014
2	Theophylline (Theon)FDA LinkGeneric 01/2016 - 06/2013
2	Bleomycin (Blenoxane)FDA LinkGeneric 09/2015 - 01/2010
2	Proteins (Proteins, Gene)FDA Link 09/2015 - 09/2014
2	Doxapram (Doxapram Hydrochloride)FDA LinkGeneric 04/2015 - 06/2013
2	Alanine Transaminase (SGPT)IBA 09/2014 - 01/2013
2	sho-seiryu-toIBA 01/2010 - 07/2009
2	Thromboxane A2 (A2, Thromboxane)IBA 10/2009 - 04/2004
2	ThromboxanesIBA 07/2009 - 04/2004
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2022
1	GangliosidesIBA 01/2022
1	Therapeutic UsesIBA 01/2021
1	IgA receptor (protein B)IBA 01/2021
1	Glycoproteins (Glycoprotein)IBA 01/2021
1	TEMPOIBA 10/2020
1	Loperamide (Imodium)FDA LinkGeneric 04/2020
1	polystyrene sulfonic acid (sodium polystyrene sulfonate)FDA LinkGeneric 04/2020
1	PotassiumIBA 04/2020
1	SphingolipidsIBA 01/2020
1	edoxabanIBA 08/2019
1	Blood Coagulation Factors (Coagulation Factor)IBA 08/2019
1	Nonprescription Drugs (Patent Medicines)IBA 01/2019
1	Valacyclovir (Valtrex)FDA LinkGeneric 01/2019
1	ethyl pyruvateIBA 02/2018
1	AntipyreticsIBA 02/2018
1	Hemoglobins (Hemoglobin)IBA 01/2017
1	Enoxaparin (Lovenox)FDA LinkGeneric 01/2017
1	CytokinesIBA 07/2016
1	InterleukinsIBA 07/2016
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 07/2016
1	CarrageenanIBA 07/2016
1	Interleukin-6 (Interleukin 6)IBA 07/2016
1	Dextrans (Dextran)FDA Link 07/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2016
1	KaolinIBA 07/2016
1	Indicators and Reagents (Reagents)IBA 11/2015
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 11/2015
1	AlbuminsIBA 11/2015
1	Serum AlbuminIBA 11/2015

Therapy/Procedure

2	Intravenous Injections 07/2009 - 04/2004
1	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2017
1	Artificial Respiration (Mechanical Ventilation) 01/2016
1	Therapeutics 01/2016
1	Length of Stay 11/2015